March 20, 2009
Love Diabetes: Do analogues cause beta cell destruction?
http://www.lovediabetes.com - Would you use an insulin analogue that caused beta cell destruction? Depending on the age of diagnosis, and type of diabetes — certain insulin analogues may not be the most ideal for the treatment of your diabetes. A non-diabetic excretes insulin with a pH of approximately 7.2 - 7.4. A non-diabetic person also has a blood pH of 7.35 — 7.45. Does the pH of your insulin analogue catalyze beta cell destruction?
Filed under Diabetes Videos by First Signs of Diabetes
Comments on Love Diabetes: Do analogues cause beta cell destruction?
Why don't more Type 2s support your statement?I used to wait for Santa Clause when I was kid — needless to say he never showed. Beta cells should NEVER have to compete with analogues. You failed to mention the insertion of an amino acid that does not exist in human insulin. And that a pH of 4 is dangerous. Long-term studies of carcinogenic effects have not been performed.
PHARMACODYNAMICS of Lantus: Lantus is designed to have low aqueous solubility at neutral pH. At pH 4, as in the Lantus injection, its completely soluble. After injection into the subcutaneous tissue the acidic solution is neutralized to 7, forming microprecipitates from which small amounts of Lantus are slowly released, resulting in a relatively constant time profile of 24 hours w/ no pronounced peak.
*MANY T-2s stop taking Lantus b/c the bcells start doing their job again.
No destruction here
Yes im using Novo Rapid and Levemir
Look at Levemir's PH ……..
Lantus has a ph of 4 (acidic)
Levemir - 7 (Neutral)
So which insulin has the ideal PH?